Epigenetic modifications, including histone modifications and DNA methylation, have effect on gene expression and regulation. Epigenetics modulators affect chromatin modification by modulating modifying enzymes and then recruting transcription factories. TACGen provides services for epigenetic modulator discovery at three level, whole genome, specific gene locus and general epigenectic modulator screening in vitro and in vivo.
DNA Methylaton Profiling
DNA methylation and demethylation is involved in chromosome condnesation and decondensation and epigenentic reprogramming of genes. TACGen provides DNA methylation whole genome mapping, specific gene locus validation and general high throughput epigenetic modulator screening in vitro and in vivo.
Histone Modification Profiling
Histone modifications are involved in transcriptional regulation, chromatin condensatio, DNA repair and replication processes. TACGen provides high-throughput histone modification whole genome mapping, specific gene locus validation and general high throughput epigenetic modulator screening in vitro and in vivo.
